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Tenofovir as an Antiretroviral Drug and Importance of CMIC in Its Manufacturing

Tenofovir is regarded as a revolutionary drug for curing and preventing AIDS/HIV. Tenofovir disoproxil has been used worldwide as an antiretroviral medication and has also proven to be helpful in fighting against another chronic disease named hepatitis B. One of the most important facts that make this medication an important one is the fact that it is on WHOs list of essential medications. CMIC is an important pharma intermediate which is used in the manufacturing of Tenofovir. However, before learning more about CMIC, it’s important to understand why Tenofovir is a revolutionary drug.


Tenofovir is medically indicated in addition to other antiretroviral medications for the treatment of HIV-1 infection. It is even known to treat pediatric patients that are at least 12 years in age. This medically proven medication is in huge demand nowadays due to the fact that chronic diseases are also becoming very common. This on the other hand has made way for a huge increase in demand for (CMIC) CAS No. 35180-01-9. Due to this, various CMIC manufacturers have started manufacturing various batches of CMIC to meet the regular demand.

Importance of CMIC in its manufacturing?

Chloromethyl Isopropyl Carbonate has a molecular formula C5H9ClO3. It is a popular pharma intermediate which aids in various applications including the manufacturing of Tenofovir. This transparent and colorless liquid has a boiling point of 147.463°C. One of the other important things to note here is that it should be packaged and stored carefully because its leakage and exposure can cause some problems.

Preparation of Tenofovir disoproxil fumarate using CMIC

1. Treating the tenofovir medication with CMIC (chloromethyl isopropyl carbonate) in a given organic solvent should be carefully done in presence of a specific base.
2. The next step should be to isolate the crystalline tenofovir disoproxil medication.
3. Next up, treating tenofovir disoproxil medication along with some fumaric acid in a suitable solvent is important.
4. At last, isolating tenofovir disoproxil fumarate is done after optionally seeding with it.

Steps involved in the Preparation of Tenofovir Disoproxil

Cyclohexane (800 ml in quantity) and Tenofovir (100 grams in quantity) are carefully added at a temperature of 25 to 35 degrees C. This process is carried out under the influence of nitrogen. The given temperature of the mixture’s reaction is precisely raised to reflux and on the other hand all the moisture is separated using azeotropic distillation. The role of CMIC starts when reaction mass is heated to 54 to 58 degrees C and CMIC is added to it. After proper processing of the mixture, the desired results are generated.

Chloromethyl Isopropyl Carbonate.

CMIC Manufacturers have really contributed a lot towards the rising demand and significance of pharma intermediates around the world. Chloromethyl isopropyl carbonate has proven to be a high quality pharma intermediate which has revolutionized the market by aiding in manufacturing tenofovir. With tenofovir helming the important task of saving lives, the future of CMIC also looks quite bright in the upcoming years.